Radmind, being a set of UNIX tools, originally supported only case-sensitive transcripts. Mac OS X’s HFS+ filesystem, developed by Apple pre-NeXT purchase, is a case-preserving, case-insensitive filesystem.
Support for case-insensitive transcripts was later added to the radmind tools.
As it turns out, it is perfectly possible to use radmind with case-sensitive transcripts to manage an OS X HFS+ filesystem. There are sometimes a few annoyances, but it generally works OK. Worst case, you might have to run the radmind tools twice to get the filesystem update when there is a case change: the first run might remove the lowercase version of the file, and the second run would install the uppercase version. Or a sharp radmind admin might be able to avoid the problem altogether by renaming files in troublesome transcripts.